Senior/Junior Postdoctoral Positions in Beta cell neogenesis at the Hubrecht Institute, Utrecht, The Netherlands.
Applications are invited for postdoctoral positions to study beta cell neogenesis as a therapy for diabetes. A decreased beta cell mass or the incapability of the beta cell mass to compensate for increased insulin needs results in an absolute (type I) or relative (type II) deficiency of insulin defining type I and type II diabetes, respectively. Our research group aims for alternative beta cell sources to compensate the reduced beta cell mass in diabetes by beta cell transplantation or by in situ differentiation and expansion of beta- and pre-beta cells. We therefore investigate mechanisms to generate new, fully functional beta cells by (i) protection and proliferation of existing beta cells, (ii) differentiation of endogenous progenitor/stem cells and regeneration of the beta cell mass and (iii) reprogramming of pancreas non-beta to beta cells.

You will work principally on the British team’s contribution in relation to the theoretical framing of the project and its application to the UK within the EU-funded project “Tolerance, Pluralism and Social Cohesion: Responding to the Challenges of the 21st Century in Europe” (ACCEPT), a cross-national collaboration with thirteen other countries.
The project, led by Professor Tariq Modood, studies the principles, practices, and institutional arrangements that are needed to promote tolerance and acceptance of cultural differences. In particular, the project questions whether European societies have become more or less tolerant recently, what tolerance means in different countries but also in the same country under different circumstances and for different issues, and whether traditional conceptions of tolerance are adequate to deliver mutual respect amongst citizens.

The ideal applicant should hold an appropriate degree from a university or technical school training in molecular and cellular biology. Proven expertise in molecular biology and biochemistry is essential; familiarity with recombineering-techniques is an advantage. Previous experience in the generation of targeting constructs (design and construction of targeting vectors) will be extremely valuable, but on-the-job training would be provided. Proficiency in basic computational skills. The successful candidate is flexible and enjoys teamwork in a dynamic environment; fluent English as well as good communication skills are essential. The candidate will interact with a variety of people and should be able to flexibly coordinate her/his work with others.
EMBL is an inclusive, equal opportunity employer offering attractive conditions and benefits appropriate to an international research organisation.

A PhD and/or Postdoctoral position is available in the Department of Microbiology and Molecular Medicine in the Centre Medicale Universitaire, Faculty of Medicine, University of Geneva, Switzerland to study the molecular mechanisms of cell-cycle control, asymmetric cell division and polarity in the genetically tractable model organism Caulobacter crescentus. Information on the current research focus can be found in the following selected articles:
Developmental Cell, in press, "Coupling prokaryotic cell fate and division control with a bifunctional and oscillating oxidoreductase homolog"

The Cell Biology and Biophysics Unit has developed an interdisciplinary approach to cell biology where physicists work closely together with cell biologists, biochemists, geneticists, developmental biologists, chemists and developers of advanced microscopy methods. As a result, the present constellation of groups covers a broad technological and conceptual field, ranging from classical cell biology to modelling and computer simulations as well as chemical biology. The research focuses on understanding the principles underlying the self-organization and function of complex and dynamic cellular structures, such as the nucleus, cytoskeleton and endomembrane system, in the context of single cells and developing embryos. We seek innovative candidates working on such morphogenetic events in living cells. We will consider outstanding candidates from any area of cell biology.

* The funds for this post are available to end of June 2012 in the first instance.
Quote Reference: PL05453,Closing Date: 24 August 2009
Interview Date(s): During September 2009

A Wellcome Trust-funded position is available from November 2009, to study cyclic AMP compartmentation and Ca2+-sensitive adenylyl cyclases in the lab of Professor Dermot Cooper. An extensive background in molecular biological methods is essential and modern imaging techniques are also desirable.

The researcher will actively contribute to the research activities in a recently established research group that aims at studying the relation of food ingredients on biomarkers of health. More precisely, he/she will participate in a project on the bio-accessibility of iron and its interaction with plant polyphenols by using an in vitro cell culture model (Caco-2).

The candidate should develop an interdisciplinary team approach. Toward this end the successful candidate will be expected to take advantage of substantial opportunities for collaboration within the department with molecular biologists as well as with the analytical chemistry platform.

Selected candidates will be included on a reserve list and may be offered a temporary assignment which can range from three months to five years under the contract agent contract.

A temporary assignment may include replacements of EMEA temporary agents (in cases of longer term absences) or to work on specific temporary projects.. Contract agent contracts cannot lead to a temporary agent contract without the successful participation in an additional open selection procedure. Contract agent contracts can not be renewed more than once.

Master of Science or equivalent

Experience from ClearCase or similar SCM systems

Experience from system design, verification and/or service operation

Experience from Java Enterprise development or similar

Fluent communication in English.

Supporting internal and external customers on the establishment and organisation of a mobile or fixed line telecommunications network.

Taking part in the management of day-to-day network operations business in terms of staffing, infrastructure & facilities, processes, finance and partnerships.

Taking part in development of strategic direction in conjunction with managers, cascading this to staff in a timely manner.

Responsible for the smooth running of operations and activities.

Maximising profitability of projects.

Promote, directly and indirectly, sales and satisfaction of products and services to clients.